Experimental studies of the effects of hypoxia on the apoptotic death of the eye
Abstract
Hypoxia plays an important role in the pathogenesis of dry eye syndrome and hereditary, dystrophic, ischaemic, inflammatory, infectious and other diseases of the eye 3,5. During hypoxia, the conditions for maintaining normal metabolism and functioning of cells are violated, which can lead to cell death. In many human eye diseases, including glaucoma, cataracts, diabetic retinopathy, and retinal dystrophy, cell death is observed by the mechanism of apoptosis 1,2,4,6,7,8,9.
Experimental studies on the effect of hypoxia on apoptotic cell death were carried out on individual eye tissues under in vitro conditions. Thus, it was shown in the culture of purified rat retinal ganglion cells, as well as corneal keratocytes, that hypoxia induces apoptosis in these cells 11,12.
The aim of this work is to study the effect of hypoxic hypoxia and acute hypobaric hypoxia on the eye tissues of adult rats in various in vivo experimental models of hypoxia.
